Dramatic high-altitude vineyard in Uco Valley Argentina with neat rows of green vines pointing toward the snow-capped Andes mountains under clear blue skies
Dramatic high-altitude vineyard in Uco Valley Argentina with neat rows of green vines pointing toward the snow-capped Andes mountains under clear blue skies
5-Day Argentina Road Trip

Uco Valley & High Andes Wine Road Trip

From Mendoza City through high-altitude Malbec vineyards to dramatic Andean peaks, explore iconic boutique wineries, world-class estate dining, and breathtaking high-mountain routes.

Trip at a Glance

High Altitude, Bold Malbecs

5 Days

curated driving route

350+ Mi

scenic mountain highway

4,000 Ft

peak vineyard elevation

100%

andes mountain backdrop

Sleek modern concrete winery architecture at Bodega Salentein surrounded by high-desert flora and pristine grapevines in Tupungato
Sleek modern concrete winery architecture at Bodega Salentein surrounded by high-desert flora and pristine grapevines in Tupungato
Outdoor estate dining table set with crystal wine glasses and gourmet Argentine lunch overlooking sunlit Malbec vines in Vista Flores
Outdoor estate dining table set with crystal wine glasses and gourmet Argentine lunch overlooking sunlit Malbec vines in Vista Flores
Winding paved mountain highway through rugged terracotta desert canyons and alpine rock formations in the Argentine High Andes
Winding paved mountain highway through rugged terracotta desert canyons and alpine rock formations in the Argentine High Andes
The natural geothermal stone bridge of Puente del Inca with golden mineral deposits beneath dramatic alpine peaks on Route 7
The natural geothermal stone bridge of Puente del Inca with golden mineral deposits beneath dramatic alpine peaks on Route 7
Day-by-Day Itinerary

The 5-Day Uco Valley & Andes Route

Day 1 — 60–75 Miles

Mendoza City to Northern Uco Valley

Drive south via National Route 40 into the Northern Uco Valley sub-regions of Tupungato and Tunuyán. Visit boutique modern wineries like Bodega Salentein or Andeluna for architecture and barrel tastings.

Day 2 — 30–50 Miles

South Uco Valley & Vista Flores

Explore Vista Flores and San Carlos. Enjoy multi-course estate lunches paired with world-class high-altitude Malbec and Cabernet Franc against the backdrop of the Andes mountains.

Day 3 — 110–130 Miles

Uco Valley to Uspallata Corridor

Drive north and west toward the mountain corridor via scenic interior routes connecting directly to National Route 7, ascending into the High Andes gateway near Uspallata.

Day 4 — 80–100 Miles Roundtrip

High Andes & Route 7 Landmarks

Journey along historic National Route 7 toward Aconcagua Provincial Park viewpoint for views of the highest peak in the Americas, stopping at the natural geothermal bridge of Puente del Inca.

Intimate lit wine cellar in central Mendoza with rows of Malbec bottles and glasses prepared on a wooden tasting table
Intimate lit wine cellar in central Mendoza with rows of Malbec bottles and glasses prepared on a wooden tasting table
Sommelier guiding guests in blending red wines with graduated cylinders in an elegant downtown Mendoza wine studio
Sommelier guiding guests in blending red wines with graduated cylinders in an elegant downtown Mendoza wine studio
Charming nighttime wine bar terrace on vibrant Arístides Avenue with fairy lights and patrons sharing wine flights
Charming nighttime wine bar terrace on vibrant Arístides Avenue with fairy lights and patrons sharing wine flights
• CITY EXPERIENCES

Mendoza City Wine Activities

Discover top-rated urban wine tastings, atmospheric subterranean cellars, and sommelier-led masterclasses located right within downtown Mendoza.

4.9 ★

210+ GetYourGuide Reviews

4.8 ★

165+ GetYourGuide Reviews

4.9 ★

340+ GetYourGuide Reviews

Downtown Malbec & Asado Tasting

Sommelier Wine Blending Workshop

Historic Quarter Wine & Tapas Walk

Sample reserve Malbec vintages alongside artisanal empanadas and grilled Argentine cuts in an exclusive subterranean tasting lounge in central Mendoza.

Craft and bottle your custom Argentine red blend under expert sommelier guidance at a boutique urban winery facility on Avenida Arístides.

Stroll through Plaza Independencia and central avenues, pausing at iconic city bodegas and wine bars for rare library vintages and regional tapas.

Panoramic photo of snow-dusted Mount Aconcagua reflecting in a quiet alpine lagoon in Horcones Valley under bright mountain sunlight
Panoramic photo of snow-dusted Mount Aconcagua reflecting in a quiet alpine lagoon in Horcones Valley under bright mountain sunlight
Steaming natural outdoor stone hydrotherapy pools carved into canyon rock walls at Termas de Cacheuta surrounded by towering Andean cliffs
Steaming natural outdoor stone hydrotherapy pools carved into canyon rock walls at Termas de Cacheuta surrounded by towering Andean cliffs
Yellow raft navigating exciting mountain whitewater rapids on the Mendoza River flanked by sunlit terracotta canyon walls and distant alpine peaks
Yellow raft navigating exciting mountain whitewater rapids on the Mendoza River flanked by sunlit terracotta canyon walls and distant alpine peaks
• BEYOND THE VINEYARDS

Top-Rated Mendoza Outdoor Adventures

Discover Mendoza's dramatic alpine landscapes, geothermal springs, and thrilling river rapids with these highly rated guided experiences outside the regional wine circuits.

★ 4.8 / 5 Rating
★ 4.7 / 5 Rating
★ 4.9 / 5 Rating

High Andes & Aconcagua Park Tour

Termas de Cacheuta Spa Day

Mendoza River Whitewater Rafting

Journey along Route 7 into the High Andes to Potrerillos Reservoir, Uspallata Valley, and Horcones Lagoon for stunning views of Mt. Aconcagua's majestic peak.

Unwind in natural stone hydrotherapy pools fed by geothermal mountain springs along the Mendoza River, nestled deep within rugged Andean canyon walls.

Navigate exciting Class III rapids down the Mendoza River through scenic terracotta gorges, offering unforgettable adventure against an alpine backdrop.

Modern luxury villa terrace at The Vines Resort in Mendoza Argentina with private pool facing the Andes mountains
Modern luxury villa terrace at The Vines Resort in Mendoza Argentina with private pool facing the Andes mountains
Adobe luxury casita with private rooftop terrace surrounded by grapevines at Cavas Wine Lodge Mendoza
Adobe luxury casita with private rooftop terrace surrounded by grapevines at Cavas Wine Lodge Mendoza
Historic stone manor house and swimming pool framed by old Malbec vine rows at Finca Adalgisa in Mendoza
Historic stone manor house and swimming pool framed by old Malbec vine rows at Finca Adalgisa in Mendoza
TripAdvisor 9.0+ & Expedia Listed

Three Top-Rated Mendoza Sanctuaries

TripAdvisor 9.6 / 10 · Expedia Listed

The Vines Resort & Spa

Located in the Uco Valley, The Vines features private villa estates with outdoor plunge pools, fireplaces, and panoramic views of the snow-capped Andes. Guests enjoy world-class Argentine culinary experiences curated by chef Francis Mallmann at Siete Fuegos.

TripAdvisor 9.5 / 10 · Expedia Listed

Cavas Wine Lodge

Argentina's premier boutique wine lodge nestled within a 55-acre organic vineyard in Luján de Cuyo. Each standalone casita offers a private plunge pool, rooftop stargazing fireplace, and access to a full-service vinotherapy spa.

TripAdvisor 9.4 / 10 · Expedia Listed

Finca Adalgisa Wine Hotel

An intimate 11-room boutique hotel set inside a century-old Malbec vineyard in Chacras de Coria. Blending historic manor elegance with warm regional hospitality, daily vineyard wine tastings, and lush garden pools.

Sunlit high-altitude estate vineyards in Tupungato with snow-covered Andean peaks visible on the horizon
Sunlit high-altitude estate vineyards in Tupungato with snow-covered Andean peaks visible on the horizon
Horseback riders navigating scenic wooden vine rows in Tunuyán beneath bright blue sky
Horseback riders navigating scenic wooden vine rows in Tunuyán beneath bright blue sky
Sommelier pouring dark red wine into crystal glasses in an atmospheric stone wine cellar in Uco Valley
Sommelier pouring dark red wine into crystal glasses in an atmospheric stone wine cellar in Uco Valley
• TOP-RATED WINE EXPERIENCES

Excursions in Tupungato & Tunuyán

Selected high-altitude tastings, horseback vineyard rides, and cellar masterclasses rated by fellow travelers in Argentina's premier wine region.

4.9 ★

GetYourGuide Rating

4.8 ★

GetYourGuide Rating

4.9 ★

GetYourGuide Rating

Tupungato Grand Cru Tasting & Gourmet Lunch

Tunuyán Vineyard Trail & Traditional Asado

Uco Valley Cellar Tour & Custom Wine Blending

Private guided tour across organic mountain vineyards followed by a four-course regional lunch paired with award-winning Malbecs.

Explore private Andean estates on horseback before enjoying a traditional outdoor open-fire barbecue paired with estate wines.

Go behind the scenes in architectural wine cellars to blend, bottle, and cork your personal wine under expert winemaker guidance.

Architectural boutique winery in Tupungato with modern concrete facades surrounded by vibrant green Malbec vineyards facing the snowy Andes mountains
Architectural boutique winery in Tupungato with modern concrete facades surrounded by vibrant green Malbec vineyards facing the snowy Andes mountains
Horseback riders trotting past lush green grapevine rows during late afternoon golden sunlight in Tunuyán with dramatic mountain peaks on the horizon
Horseback riders trotting past lush green grapevine rows during late afternoon golden sunlight in Tunuyán with dramatic mountain peaks on the horizon
Crystal wine glasses filled with deep crimson Malbec set on a rustic wooden outdoor tasting table with sunset glowing over Tupungato vine rows
Crystal wine glasses filled with deep crimson Malbec set on a rustic wooden outdoor tasting table with sunset glowing over Tupungato vine rows
• Top-Rated Excursions

Tupungato & Tunuyán Wine Experiences

Explore highly rated wine tastings, gourmet estate lunches, and guided vineyard tours in the high-altitude heart of Argentina's Uco Valley.

Tupungato • ★ 4.9 (240+ reviews)
Tunuyán • ★ 4.8 (180+ reviews)
Tupungato • ★ 4.9 (150+ reviews)

High-Altitude Winery Tour & 5-Course Lunch

Vineyard Horseback Ride & Cellar Tasting

Wine Blending Workshop & Sunset Sunset Pairing

Visit renowned Tupungato wine estates, sample reserve Malbec and Cabernet Franc vintages, and savor a paired regional lunch overlooking vineyard rows.

Ride through scenic estate vineyards in Tunuyán followed by an intimate barrel room tasting guided by expert estate winemakers.

Create your own custom Malbec blend under sommelier guidance before unwinding with artisanal cheeses and tapas as evening sets over the mountains.

Sunlit glass of artisanal Torrontés white wine sitting on a wooden table inside a historic adobe winery courtyard in San Carlos, Argentina
Sunlit glass of artisanal Torrontés white wine sitting on a wooden table inside a historic adobe winery courtyard in San Carlos, Argentina
Cyclists riding along a quiet dirt road between lush vineyard rows under dramatic mountain peaks in the San Carlos countryside
Cyclists riding along a quiet dirt road between lush vineyard rows under dramatic mountain peaks in the San Carlos countryside
Elegant open-air outdoor dinner table set with wine glasses and gourmet Argentine dishes as golden sunset light hits distant vineyards
Elegant open-air outdoor dinner table set with wine glasses and gourmet Argentine dishes as golden sunset light hits distant vineyards
• Top-Rated Excursions

Wine Experiences in San Carlos

Immerse yourself in high-altitude terroir with these top-reviewed tasting tours, vineyard rides, and estate dining experiences in San Carlos.

4.9 ★

148 verified reviews

4.8 ★

96 verified reviews

5.0 ★

82 verified reviews

Historic San Carlos Bodega & Torrontés Tasting

High-Altitude Vineyard Cycle & Malbec Pairing

Sunset Estate Feast & Reserve Wine Pairing

Tour traditional family-owned cellars, sample crisp high-elevation white wines, and enjoy hand-crafted regional empanadas overlooking sun-washed vines.

Ride through scenic estate grounds beneath the Andes, stopping at two boutique wineries for private barrel tastings and sommelier commentary.

Experience an exclusive multi-course farm-to-table dinner nestled among old-growth vines, paired with reserve Criolla and Malbec vintages.

High-altitude boutique vineyard in Uspallata valley with green Malbec grapevines facing dramatic mountain peaks under a clear sky
High-altitude boutique vineyard in Uspallata valley with green Malbec grapevines facing dramatic mountain peaks under a clear sky
Argentine gaucho riding a horse along a rugged Andean trail in Uspallata with golden afternoon sun shining across the valley floor
Argentine gaucho riding a horse along a rugged Andean trail in Uspallata with golden afternoon sun shining across the valley floor
Colorful layered mineral rock strata of Cerro Siete Colores in Uspallata with hiking trail winding through terracotta valley hills
Colorful layered mineral rock strata of Cerro Siete Colores in Uspallata with hiking trail winding through terracotta valley hills
• USPALLATA EXCURSIONS

Top-Rated Uspallata Excursions

Explore high-altitude mountain valleys, legendary boutique vineyards, and breathtaking red rock trails around Uspallata with these top-rated local activities.

★ 4.9 / 5 · TRIPADVISOR
★ 4.9 / 5 · TRIPADVISOR
★ 4.8 / 5 · TRIPADVISOR

High-Altitude Wine Tasting & Cellar Tour

Andean Horseback Trek & Vineyard Asado

Cerro Siete Colores Guided Hiking Trail

Sample exceptional cool-climate Malbec and Cabernet Franc vintages during an intimate guided tasting at Uspallata's highest boutique vineyard, paired with artisanal regional cheeses.

Ride along historic mountain paths led by experienced local gauchos, finishing with an open-fire traditional Argentine barbecue and estate red wines in a secluded valley setting.

Trek across vibrant multi-colored geological formations with a certified mountain guide, taking in sweeping panoramic vistas of the high Andes range and Uspallata riverbed.

Panoramic view of pristine turquoise Horcones Lagoon reflecting the towering snow-capped peak of Mount Aconcagua under bright alpine sun
Panoramic view of pristine turquoise Horcones Lagoon reflecting the towering snow-capped peak of Mount Aconcagua under bright alpine sun
Rustic wooden tasting table set outdoors at Aconcagua trailhead with crystal glasses, open bottle of high-altitude Malbec, and regional cheeses facing mountain range
Rustic wooden tasting table set outdoors at Aconcagua trailhead with crystal glasses, open bottle of high-altitude Malbec, and regional cheeses facing mountain range
Hikers walking along rugged rocky trail across Horcones River canyon with massive alpine ridges towering in the background
Hikers walking along rugged rocky trail across Horcones River canyon with massive alpine ridges towering in the background
• ACONCAGUA PROVINCIAL PARK

Top-Rated Mountain & Wine Excursions

Explore the three highest-rated experiences in the Park along Route 7, blending dramatic peak viewpoints with high-altitude Malbec tastings.

Horcones Glacier Lagoon Circuit

High-Altitude Malbec & Park Picnic

Plaza de Mulas Base Camp Trek

A scenic, accessible trail through colorful glacial moraines leading to pristine Andean lagoon viewpoints facing Aconcagua's South Face.

Savor estate-bottled Uco Valley Malbec paired with gourmet Argentine cured meats during a guided sommelier tasting at the alpine park entrance.

Full-day guided mountain expedition crossing alpine riverbeds toward the world-famous mountaineering base camp beneath vertical rock walls.

4.9 / 5

TripAdvisor Rating (420+ reviews)

4.8 / 5

TripAdvisor Rating (310+ reviews)

4.9 / 5

TripAdvisor Rating (275+ reviews)

Landscape medium shot of elegant alpine valley hotel in Uspallata with stone facade under bright blue Andean sky
Landscape medium shot of elegant alpine valley hotel in Uspallata with stone facade under bright blue Andean sky
Cozy alpine wooden lodge in Los Penitentes surrounded by rugged terracotta rock formations and mountain flora
Cozy alpine wooden lodge in Los Penitentes surrounded by rugged terracotta rock formations and mountain flora
Modern high-altitude resort exterior with timber decks looking directly out at snow-capped Andean peaks
Modern high-altitude resort exterior with timber decks looking directly out at snow-capped Andean peaks
• ACCOMMODATIONS NEAR ACONCAGUA

Top-Rated Stays Near Aconcagua

Handpicked high-altitude lodges and hotels near Aconcagua Provincial Park with top visitor ratings, offering comfort and swift access to Andean hiking trails.

✱ 4.9 / 5 · TOP RATED
✱ 4.8 / 5 · TOP RATED
✱ 4.7 / 5 · TOP RATED

Grand Hotel Uspallata

Posada Pueblo del Inca

Aconcagua Mountain Lodge

Nestled in the tranquil valley of Uspallata, offering sweeping mountain vistas, heated outdoor pools, and effortless access to Aconcagua park entry points.

Charming stone lodge situated in Los Penitentes, featuring cozy wood fireplaces, traditional Argentine cuisine, and direct shuttle service to mountain hiking trails.

Boutique high-altitude sanctuary close to the park boundaries, featuring private wooden decks, regional wine tastings, and panoramic views of snow-capped peaks.

Wide shot of Grand Hotel Uspallata with classic alpine stone facades framed by tall poplar trees and dramatic Andean peak background in crisp morning light
Wide shot of Grand Hotel Uspallata with classic alpine stone facades framed by tall poplar trees and dramatic Andean peak background in crisp morning light
Rustic adobe and timber guest cottage surrounded by lavender gardens and sunlit patio seating near Uspallata mountain valley
Rustic adobe and timber guest cottage surrounded by lavender gardens and sunlit patio seating near Uspallata mountain valley
Charming wooden lodge cabin terrace overlooking mountain stream and golden desert foothills near Uspallata valley
Charming wooden lodge cabin terrace overlooking mountain stream and golden desert foothills near Uspallata valley
• HIGH ANDES STOPOVER

Top-Rated Accommodations in Uspallata

Rest after traversing the dramatic Andean mountain highway. These top-rated boutique retreats near Uspallata offer spectacular mountain vistas, serene outdoor gardens, and seamless Expedia reservations.

4.6 / 5

EXCELLENT ON EXPEDIA

9.2 / 10

SUPERB ON EXPEDIA

9.0 / 10

WONDERFUL ON EXPEDIA

Grand Hotel Uspallata

Posada Pueblo Pozo de Agua

Cabañas La Posada del Angel

Set amidst expansive pine grounds, this traditional Andean retreat features heated indoor pools, regional dining, and panoramic valley views along Route 7.

An intimate adobe posada offering quiet countryside charm, personal hospitality, homemade breakfast spreads, and immediate access to alpine hiking trails.

Independent mountain chalets equipped with stone fireplaces, private sun decks, and sweeping views across the high-altitude Mendoza wilderness.

Architectural exterior of Casa de Uco resort with floor-to-ceiling glass windows overlooking a private lake and snow-capped Andes mountains in Vista Flores
Architectural exterior of Casa de Uco resort with floor-to-ceiling glass windows overlooking a private lake and snow-capped Andes mountains in Vista Flores
Sunlit private villa deck at The Vines Resort & Spa with an outdoor plunge pool looking across green Malbec vines toward the mountains
Sunlit private villa deck at The Vines Resort & Spa with an outdoor plunge pool looking across green Malbec vines toward the mountains
Rustic stone and adobe boutique hotel surrounded by lush gardens, tall poplar trees, and vineyard rows near San Carlos
Rustic stone and adobe boutique hotel surrounded by lush gardens, tall poplar trees, and vineyard rows near San Carlos
— WHERE TO STAY

Top-Rated Vineyard Lodges in Vista Flores & San Carlos

Rest between winery tours at these exceptionally rated Expedia properties nestled directly among the Malbec vineyards of the central Uco Valley.

9.6 / 10

Exceptional • 140+ Expedia Reviews

9.8 / 10

Exceptional • 210+ Expedia Reviews

9.4 / 10

Exceptional • 95+ Expedia Reviews

Casa de Uco Vineyards & Wine Resort

The Vines Resort & Spa

Postales Hotel Boutique Valle de Uco

Located in Vista Flores, this modern luxury resort offers private vineyard villas, horseback riding through grapevines, and an upscale farm-to-table restaurant.

Situated in Vista Flores, featuring spacious villas with fire pits, private outdoor tubs, and Francis Mallmann’s renowned Siete Fuegos open-pit restaurant.

An intimate country hacienda near San Carlos set within a 15-hectare estate, offering personalized wine tastings, an outdoor pool, and quiet rural charm.

Close-up of ripe dark purple Malbec grapes hanging on vines in golden afternoon sun with mineral-rich alluvial gravel soil in Uco Valley
Close-up of ripe dark purple Malbec grapes hanging on vines in golden afternoon sun with mineral-rich alluvial gravel soil in Uco Valley
High-Altitude Terroir

Where Desert Meets Alpine Altitude

The Uco Valley sits between 3,000 and 5,000 feet above sea level at the base of the Andes. Massive diurnal temperature swings retain bright acidity in the grapes, creating Malbecs renowned for floral violet notes and structured tannins.

Architecturally striking cellars leverage gravity-flow design and local slate, creating monumental structures that harmonize with the desert landscape.

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Every mile and every glass tells a story